Name: Chicken and Spinach Casserole with Cream Cheese
Prep time: 15 min
Cook time: 30 min
Total time: 45 min
Ingredients: 2 tablespoons olive oil; 1½ pounds boneless, skinless chicken breasts, cubed; 2 teaspoons garlic powder; Salt and black pepper to taste; 5 ounces fresh spinach (or 10 ounces frozen, thawed and drained); 8 ounces cream cheese, softened; ½ cup sour cream; ½ cup grated Parmesan cheese; 1 cup shredded mozzarella cheese; ½ teaspoon onion powder; ¼ teaspoon crushed red pepper flakes (optional)

Golden-baked and irresistibly creamy, this Chicken and Spinach Casserole with Cream Cheese is the ultimate comfort food in one dish. Juicy bites of chicken are nestled among tender spinach, all coated in a velvety cream cheese sauce and topped with a golden, bubbly layer of cheese. Every forkful brings warmth, richness, and a balanced blend of flavor that’s both hearty and satisfying.

This casserole isn’t just about indulgence—it’s also practical and nourishing. The spinach adds a burst of nutrients, while the cream cheese brings depth without overwhelming the dish. Whether you’re feeding a hungry family or prepping meals for the week, this dish covers all bases with ease, comfort, and just the right amount of decadence.

Why You’ll Love This Chicken and Spinach Casserole with Cream Cheese

Perfect Balance of Flavor: Creamy, savory, slightly garlicky, and just enough cheese to feel indulgent without being too heavy.
Family-Friendly: Even picky eaters will go for seconds.
One-Dish Wonder: Easy to prepare and serve from a single pan—less cleanup, more enjoyment.
Freezer-Friendly: Great for meal prep and saving leftovers for busy days.
Nutrient-Packed: Packed with spinach and lean protein for a wholesome meal.

Preparation Phase & Tools to Use (Essential Tools and Equipment, and the Importance of Each Tool)

To create a smooth and stress-free cooking experience, having the right tools ready is key. Here’s what you’ll need:

Large Skillet or Sauté Pan: This is where you’ll cook your chicken and wilt the spinach. A wide surface area allows for even cooking and prevents overcrowding.
Mixing Bowl: Perfect for combining your cream cheese mixture with other ingredients like garlic, seasoning, and cheese.
9×13-inch Baking Dish: The ideal size for layering everything together and baking evenly. Ceramic or glass works great for even heat distribution.
Wooden Spoon or Silicone Spatula: Great for stirring the creamy mixture without scratching your cookware.
Sharp Knife and Cutting Board: For prepping the chicken and any optional add-ins like onions or herbs.
Whisk: Optional but useful if you want an ultra-smooth cream cheese base before mixing it with the chicken and spinach.

Preparation Tips

Soften the Cream Cheese: Let it sit at room temperature for about 30 minutes before mixing. This makes it much easier to combine with other ingredients.
Use Fresh or Frozen Spinach: If using frozen, thaw it completely and squeeze out excess moisture to avoid a watery casserole.
Sear the Chicken: Lightly browning the chicken cubes before baking adds depth of flavor and improves the final texture.
Season Generously: Cream cheese can mellow out bold flavors, so don’t be shy with garlic, salt, pepper, or Italian seasoning.
Preheat Your Oven: Make sure your oven is fully preheated to ensure the casserole cooks evenly and achieves a golden top.

Ingredients for This Chicken and Spinach Casserole with Cream Cheese

Here’s everything you’ll need to bring this creamy, cheesy, comforting casserole to life:

2 tablespoons olive oil – for sautéing the chicken
1½ pounds boneless, skinless chicken breasts – cut into bite-sized chunks
2 teaspoons garlic powder – for aromatic depth
Salt and black pepper to taste – to season the chicken
5 ounces fresh spinach – or use 10 ounces frozen, thawed and squeezed dry
8 ounces cream cheese, softened – the creamy heart of the dish
½ cup sour cream – adds tang and smoothness
½ cup grated Parmesan cheese – nutty, salty richness
1 cup shredded mozzarella cheese – for the gooey topping
½ teaspoon onion powder – subtle background flavor
¼ teaspoon crushed red pepper flakes (optional) – a gentle kick of heat

Optional Add-ins:

Chopped onions – sautéed with the chicken
Fresh herbs like parsley or thyme – for garnish and freshness
Cooked pasta or rice – for turning this into a complete one-pan meal

Step 1: Prepare and Season the Chicken

Preheat your oven to 375°F (190°C). While it heats, cut the chicken into bite-sized pieces. Heat olive oil in a large skillet over medium-high heat, then add the chicken. Season with garlic powder, salt, and pepper. Sear for 4–5 minutes until the chicken is lightly browned but not fully cooked through. Remove from heat and set aside.

Step 2: Wilt the Spinach

In the same skillet, add a touch more oil if needed and toss in the spinach. Sauté just until wilted (or heat frozen spinach until fully warmed through). Make sure to remove any excess moisture so the casserole doesn’t turn watery.

Step 3: Make the Creamy Base

In a large mixing bowl, combine softened cream cheese, sour cream, onion powder, and half of the Parmesan cheese. Whisk until smooth and creamy. Add crushed red pepper flakes if using, and fold in the cooked spinach.

Step 4: Assemble the Casserole

Spread half of the cream cheese mixture in the bottom of your 9×13-inch baking dish. Layer the seared chicken on top, then spoon the remaining creamy mixture over the chicken. Sprinkle mozzarella and the remaining Parmesan cheese evenly on top.

Step 5: Bake to Perfection

Bake uncovered in the preheated oven for 25–30 minutes, or until the top is bubbly and golden brown and the chicken is cooked through. Let it rest for 5–10 minutes before serving to allow everything to set.

Notes

Chicken Alternatives: Boneless, skinless chicken thighs can be used for extra juiciness.
Low-Carb Friendly: This casserole is naturally low in carbs—ideal for keto-style eating.
Make Ahead: You can assemble the casserole a day in advance. Just cover and refrigerate, then bake when ready.
Cheese Options: Feel free to mix in sharp cheddar, Gruyère, or fontina for a twist on the cheese blend.
Boost Veggie Power: Add sautéed mushrooms or zucchini for more texture and nutrition.

Watch Out for These Mistakes While Cooking

Not Draining Spinach Well: Excess moisture can make the casserole runny. Always press out water from thawed or sautéed spinach.
Overcooking the Chicken in the Skillet: Remember, it finishes cooking in the oven. Browning is enough.
Using Cold Cream Cheese: If it’s too firm, it won’t blend well and may leave lumps.
Skipping Seasoning: With cream cheese and spinach being mild, you’ll want to season generously for bold flavor.
Baking Too Long: Overbaking can dry out the chicken and curdle the cheese. Check it around the 25-minute mark.

What to Serve With Chicken and Spinach Casserole with Cream Cheese?

Pair this rich and creamy casserole with lighter, refreshing, or complementary sides to balance out the flavors and textures of your meal.

8 Recommendations

Garlic Roasted Broccoli – The crispy edges and subtle garlic flavor provide a fresh contrast.
Simple Mixed Green Salad – A zesty vinaigrette helps cut through the richness of the casserole.
Cauliflower Rice – Keeps it low-carb while adding texture and soaking up the creamy sauce.
Buttery Mashed Potatoes – A classic side that complements the comforting profile.
Crusty Artisan Bread – Ideal for scooping up every bit of sauce from the plate.
Steamed Green Beans with Lemon – Bright and tender, offering a light sidekick.
Herbed Quinoa – Nutty and fresh, a high-protein grain that balances the creaminess.
Roasted Carrots with Thyme – Slight sweetness and earthy herbs pair beautifully with the savory casserole.

Storage Instructions

To keep your Chicken and Spinach Casserole with Cream Cheese fresh and flavorful:

Refrigerator: Store leftovers in an airtight container or cover the baking dish with foil. It will stay good for up to 4 days in the fridge.
Freezer: This casserole freezes beautifully. Wrap it tightly in plastic wrap and foil, or use a freezer-safe container. It will last up to 2 months.
To Reheat: Warm in the oven at 350°F (175°C) for 15–20 minutes, or until heated through. If reheating from frozen, let it thaw in the fridge overnight first for best results.

Estimated Nutrition (Per Serving — based on 6 servings)

Calories: 410
Protein: 32g
Carbohydrates: 6g
Fat: 28g
Fiber: 1g
Sugar: 2g
Sodium: 530mg

Note: Values may vary slightly depending on the specific ingredients and brands used.

Frequently Asked Questions

1. Can I use rotisserie chicken instead of raw chicken?

Yes! Rotisserie chicken works wonderfully and saves time. Just shred it and mix it in during the layering step—skip the stovetop searing.

2. Is it okay to use low-fat cream cheese?

Absolutely. Low-fat cream cheese will work, but the sauce may be slightly less rich and creamy.

3. Can I make this casserole vegetarian?

You can! Swap the chicken for sautéed mushrooms, cooked lentils, or chickpeas for a satisfying vegetarian version.

4. Will this recipe work with dairy-free cheese?

Yes, dairy-free cheese and cream cheese alternatives can be used. Choose ones that melt well for best texture.

5. Can I double the recipe for a crowd?

Yes, just use a larger baking dish or two standard 9×13 pans, and increase the baking time by 5–10 minutes.

6. How can I make this spicier?

Add more red pepper flakes or mix in chopped jalapeños or a splash of hot sauce to the cream cheese mixture.

7. What’s the best way to thaw frozen spinach?

Place it in a colander and run warm water over it, then squeeze out all the excess moisture using a clean towel or paper towels.

8. Can I assemble it ahead of time?

Yes, you can prep the entire dish up to a day in advance and refrigerate it. Bake just before serving.

Conclusion

Chicken and Spinach Casserole with Cream Cheese is the definition of a cozy, crave-worthy dish that’s as simple to make as it is satisfying to eat. Creamy, cheesy, and full of protein and greens, it’s the kind of recipe that turns a busy weeknight or a casual dinner into something special. Whether you’re meal prepping, feeding a family, or looking for a hearty dish to share, this casserole will quickly become a go-to favorite.