Name: Chicken Bubble Biscuit Bake Casserole
Prep time: 15 min
Cook time: 40 min
Total time: 55 min
Cuisine: American
Ingredients: 2 cups cooked chicken, shredded or chopped; 1 can (10.5 oz) cream of chicken soup; 1 cup sour cream; 1 cup shredded cheddar cheese; 1 tube (16 oz) refrigerated biscuit dough; 1/2 teaspoon garlic powder; 1/2 teaspoon onion powder; 1/4 teaspoon salt; 1/4 teaspoon black pepper; 1 tablespoon chopped parsley for garnish

I’ve always had a soft spot for comfort food that feels like a warm hug, and this Chicken Bubble Biscuit Bake Casserole hits all the right notes. It’s creamy, savory, and bursting with cheesy goodness, all tucked under golden-brown, fluffy biscuits. I first stumbled upon this idea during a rushed weeknight when I had leftover rotisserie chicken and a tube of biscuit dough—what came out of the oven was pure magic.

Over time, I’ve refined this recipe into something that’s now a weekly favorite in my home. It’s quick to prep, kid-approved, and perfect for potlucks or lazy Sundays. The tender chunks of chicken mixed with a creamy sauce and gooey cheese, then topped with biscuit bites that puff up like golden pillows—this casserole is more than dinner, it’s therapy in a dish.

Why You’ll Love This Chicken Bubble Biscuit Bake Casserole

It’s not just easy—it’s a crowd-pleaser. This casserole is built for comfort and speed. The creamy base makes every bite rich and satisfying, while the biscuits offer a fluffy and crispy contrast that’s addictive. Whether you’re feeding picky eaters or a hungry family, this dish checks every box. Plus, it’s a great way to use up leftover chicken and stretch ingredients into a full meal.

What Kind of Biscuits Should I Use?

You’ll want to use refrigerated biscuit dough for this recipe—specifically the kind that comes in a tube. The “buttermilk” or “southern style” versions work best since they hold their shape and offer that rich, buttery taste. Avoid the flaky layered style as they can separate too much during baking and won’t puff up quite the same.

Options for Substitutions

No rotisserie chicken on hand? You can swap it out with cooked turkey, shredded pork, or even canned chicken in a pinch. For the sauce, cream of mushroom or cream of celery works as a substitute for cream of chicken. Want it vegetarian? Go with cream of mushroom and add steamed broccoli or sautéed mushrooms. And if you’re dairy-free, look for plant-based cream soups and cheeses to adapt it without sacrificing flavor.

Ingredients for this Chicken Bubble Biscuit Bake Casserole

Cooked chicken – This is the heart of the dish, providing protein and that savory, comforting flavor. Rotisserie chicken works beautifully for both convenience and taste.

Refrigerated biscuit dough – These biscuits puff up into golden, fluffy bites that soak up the creamy sauce beneath. They add texture and make the dish ultra-satisfying.

Cream of chicken soup – The base of the sauce, adding richness and a smooth, creamy texture that holds the whole casserole together.

Sour cream – This gives the sauce a nice tang and extra creaminess, balancing the savory elements.

Cheddar cheese – Melted into the sauce and sprinkled on top, it adds that cheesy, gooey factor that makes this casserole irresistible.

Garlic powder, onion powder, salt, and black pepper – These bring flavor depth and balance, seasoning the entire dish just right.

Chopped parsley – Used as a garnish, it adds a pop of color and a hint of freshness.

Step 1: Preheat and Prep

Preheat your oven to 350°F (175°C). Lightly grease a 9×13-inch baking dish with cooking spray or butter. This helps prevent sticking and ensures easy cleanup.

Step 2: Mix the Creamy Base

In a large mixing bowl, combine the cream of chicken soup, sour cream, garlic powder, onion powder, salt, and pepper. Stir until smooth and fully blended. This is your flavorful sauce foundation.

Step 3: Add the Chicken

Fold the shredded or chopped cooked chicken into the creamy mixture. Make sure the pieces are evenly coated. This ensures every bite is packed with flavor.

Step 4: Cut and Toss the Biscuits

Open the biscuit dough tube and cut each biscuit into quarters. Gently toss the biscuit pieces into the chicken mixture, making sure they’re coated in the sauce. This helps them bake into tender, flavorful pillows.

Step 5: Layer It All In

Pour the entire mixture into your prepared baking dish. Spread it out evenly, and sprinkle the shredded cheddar cheese over the top for that cheesy, bubbly finish.

Step 6: Bake Until Golden and Bubbling

Bake uncovered for 35 to 40 minutes or until the biscuits are golden brown on top and cooked through in the center. The cheese should be melted and lightly browned.

Step 7: Garnish and Serve

Remove from the oven and let it rest for 5 minutes. Sprinkle with chopped parsley for a pop of color. Serve warm and enjoy every bite of this cozy casserole.

How Long to Prepare the Chicken Bubble Biscuit Bake Casserole

Prep Time: The hands-on prep is surprisingly quick. From chopping the chicken to mixing the sauce and cutting the biscuits, it takes about 10–15 minutes. Using pre-cooked or rotisserie chicken makes it even faster.

Bake Time: The dish needs about 35–40 minutes in the oven. You’ll know it’s done when the biscuits are puffed and golden on top, and the creamy base is bubbling at the edges.

Tips for Perfect Chicken Bubble Biscuit Bake Casserole

Use room temperature sour cream and soup for easier mixing.
Lightly grease the baking dish to avoid any sticky mess from the biscuits or cheese.
Don’t overcrowd the biscuit pieces—they need space to puff and brown evenly.
Let it rest for a few minutes before serving to allow the sauce to thicken slightly.
Add a sprinkle of extra cheese in the last 5 minutes of baking for a cheesy crust.

Watch Out for These Mistakes While Cooking

Using raw biscuit dough without spacing: If the dough is too clumped together, the centers may remain undercooked.
Not preheating the oven: It’s essential for getting that golden crust on top.
Overmixing the biscuit pieces: This can break them down too much. Gently fold them in.
Forgetting to check doneness: Insert a toothpick in the center biscuit piece—if it comes out doughy, bake a bit longer.
Skipping the garnish: A touch of parsley or green onions adds brightness and visual appeal.

What to Serve With Chicken Bubble Biscuit Bake Casserole?

1. Simple Garden Salad

A crisp salad with lettuce, cherry tomatoes, cucumbers, and vinaigrette adds freshness to balance the creamy casserole.

2. Steamed Green Beans

Lightly seasoned green beans offer a healthy, crunchy contrast.

3. Roasted Brussels Sprouts

Tossed with olive oil, salt, and pepper, they bring a caramelized flavor that pairs perfectly.

4. Cranberry Sauce

That sweet-tart burst is a surprisingly great complement to the creamy, savory bake.

5. Garlic Butter Corn on the Cob

Adds buttery sweetness and a pop of color to the plate.

Storage Instructions

Refrigerating: Let the casserole cool completely before transferring leftovers to an airtight container. Store in the refrigerator for up to 4 days. Reheat in the oven at 325°F for about 10–15 minutes or until warmed through.

Freezing: This dish can be frozen after baking. Allow it to cool, then wrap tightly with foil and freeze for up to 2 months. To reheat, bake straight from frozen at 350°F, covered, for 45–50 minutes, then uncover for the last 10 minutes to crisp up the top.

Estimated Nutrition

Per serving (based on 6 servings):

Calories: 450–500 kcal
Protein: 26g
Carbohydrates: 32g
Fat: 25g
Saturated Fat: 10g
Sodium: 950mg
Sugar: 4g
Fiber: 2g

Frequently Asked Questions

How do I know the biscuits are fully cooked?

They should be golden brown on top. You can also insert a toothpick in the center—if it comes out clean or with just melted cheese, they’re ready.

Can I make this casserole ahead of time?

Yes, you can prep the creamy mixture and chicken ahead of time, but don’t add the biscuits until right before baking to keep them from getting soggy.

What other cheese can I use?

Monterey Jack, mozzarella, or Colby Jack are great options. You can also mix two kinds for more depth.

Can I use homemade biscuit dough?

Definitely! Just be sure it’s a drop biscuit style dough, not a layered one.

Is this recipe kid-friendly?

Absolutely. Kids love the creamy texture and cheesy biscuit topping. It’s also mild in flavor but customizable if you want a kick.

Conclusion

The Chicken Bubble Biscuit Bake Casserole is everything a comfort dish should be—warm, creamy, cheesy, and topped with golden bites of biscuit. It’s simple to make, endlessly adaptable, and sure to be a hit at the dinner table. Whether you’re feeding your family on a busy weeknight or serving guests at a casual gathering, this casserole brings everyone back for seconds.